PREPARATION AND ANTIMICROBIAL ACTIVITY OF NUCLEOBASE-CONJUGATED CDTE/ZNSE CORE/SHELL QUANTUM DOTS

1,2 MOULICK Amitava
Co-authors:
1,2 CIHALOVA Kristyna 1,2 MILOSAVLJEVIC Vedran 1,2 KOPEL Pavel 1,2 ADAM Vojtech 1,2 HEGER Zbyněk 1,2 KIZEK Rene
Institutions:
1 Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic, EU
2 Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech Republic, EU
Conference:
7th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 14th - 16th 2015
Proceedings:
Proceedings 7th International Conference on Nanomaterials - Research & Application
Pages:
537-541
ISBN:
978-80-87294-59-8
ISSN:
2694-930X
Published:
11th January 2016
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
23 views / 2 downloads
Abstract

Inorganic nanomaterials have large specific surface area and high bioactivity which made them promising alternatives to the traditional organic antimicrobial agents that are extremely irritant and toxic. In the present report, CdTe/ZnSe core/shell quantum dots (QDs) were conjugated with different nucleobases and their antibacterial activity against Escherichia coli was investigated. The CdTe/ZnSe core/shell QDs were synthesized in a green way or environment-friendly way using water as a solvent instead of organic solvents. They were successfully conjugated with different nucleobases and were characterized using fluorescence and absorbance spectrophotometry and dynamic light scattering techniques. The antimicrobial activity of all the samples along with control (bare QDs) was checked on E. coli, a commonly used bacterial model species in microbiology research. Almost all nucleobases showed good antibacterial activity comparing to control probably forming excess ROS which can disturb different metabolic pathways in bacterial cell. Guanine showed the best result among all other nucleobases.

Keywords: Quantum dots, nucleobases, antibacterial activity
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