CONTROLLED RELEASE FROM LAYERED NANOSTRUCTURED MATERIALS DRIVEN BY CAPILLARY FORCES

1,2 SUDAKOVA Anna
Co-authors:
5 NGUYEN Duc Anh 3 MINH HA Le 2 SMILEK Jiri 4 NGO Thi Phuong 1 ZIDEK Jan
Institutions:
1 CEITEC – Central European Institute of Technology, Brno, Czech Republic, EU, Anna.Sudakova@ceitec.vutbr.cz, jan.zidek@ceitec.vutbr.cz
2 Institute of Physical and Applied Chemistry, Faculty of Chemistry, Brno, Czech Republic, EU, smilek@fch.vut.cz
3 Institute of Natural Products Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), Nghia Do, Cau Giay, Hanoi, Viet Nam, halm2vn@gmail.com
4 Phenikaa University Nano Institute (PHENA), Phenikaa University, Hanoi, Vietnam, thuy.nguyenthithu@phenikaa-uni.edu.vn
5 Center for Research and Technology transfer, Vietnam Academy of Science and Technology (VAST), Nghia Do, Cau Giay, Hanoi, Viet Nam, ducanh221100@gmail.com
Conference:
14th International Conference on Nanomaterials - Research & Application, OREA Congress Hotel Brno, Czech Republic, EU, October 19 - 21, 2022
Proceedings:
Proceedings 14th International Conference on Nanomaterials - Research & Application
Pages:
194-199
ISBN:
978-80-88365-09-9
ISSN:
2694-930X
Published:
23rd November 2022
Proceedings of the conference have already been published in Scopus and we are waiting for evaluation and potential indexing in Web of Science.
Metrics:
243 views / 88 downloads
Abstract

Controlled release of active compounds has been investigated in current medical research and there were developed many approaches, how to control it. For instance, complexation of active compound, encapsulation in matrix, or release from gels. However, there are still opportunities to improve its mechanisms.This contribution presents potentially promising method of controlled release, which is based on two modifications of standard mechanisms: i. release from nanostructured layered material, ii. release forced by capillarity. That mechanism allows us to design systems with gradual release of the active substance.The release of indigotin dye was performed from materials where layers of non-woven chitosan fabric alternate with gelatine layers. Active compound was incorporated in each layer. Gradual wetting of layers is caused by capillarity effect. The controlled release can be observed visually, e.g. by optical spectroscopy. In the future, the colour compound will be substituted by medical active substances, such as antibiotics etc.The final systems will be composed of natural and biocompatible materials, such as polysaccharides and proteins. The active compound will be in synergy with the chitosan matrix. Chitosan is a unique natural polymer with positive charge on the surface, it exhibits mucoadhesive and antibacterial properties. Gelatine was chosen because it is a protein with a negative charge on its surface, which forms a polyionic mixture with positively charged chitosan.Such material will improve the current practice in the field of medical materials. It will allow us to design patches treated with an active substance that could improve the therapeutic effect.

Keywords: Chitosan, nanostructured gel, controlled release, capillary force, layered material

© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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