APPLICATION OF PHB-LIPOSOME PARTICLES AND NANOFIBERS IN COSMETICS

1 PAVELKOVÁ Renata
Co-authors:
1 PLACHÁ Monika 1 TARAGEĽ Matej 1 BENDOVÁ Agáta 1 MATOUŠKOVÁ Petra 1 MÁROVÁ Ivana
Institution:
1 Institute of Food Science and Biotechnology, Faculty of Chemistry, Brno University of Technology, 612 00 Brno, xcpavelkovar@fch.vut.cz
Conference:
11th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 16th - 18th 2019
Proceedings:
Proceedings 11th International Conference on Nanomaterials - Research & Application
Pages:
514-519
ISBN:
978-80-87294-95-6
ISSN:
2694-930X
Published:
1st April 2020
Proceedings of the conference have been sent to Web of Science and Scopus for evaluation and potential indexing.
Metrics:
14 views / 2 downloads
Abstract

Liposomes are versatile systems for drug delivery. They are utilized in various industries such as pharmaceutical, food industry and cosmetics. Even though they are capable to encapsulate both hydrophilic and lipophilic compounds, they can be modified using cholesterol, proteins and polymers to enhance their properties.Presented work is focused on development and preparation of PHB-liposomes particles with different PHB content as well as PHB nanofibers. Characterization in terms of particle size, polydispersity index, colloidal stability and long-term stability were done. Sun protection factor was measured, too. Electron microscopy techniques (SEM, cryoTEM) were used to observe structure of prepared materials. To assess whether prepared particles are suitable for further application in cosmetics, MTT and LDH cytotoxicity assays on HaCaT cell line were carried out.Our goal was to prepare and characterize PHB containing liposomes and nanofibers for potential application in cosmetic, pharmaceutical and food industry. Prepared particles were stable and had proper properties to be used as vehicles. Cytotoxicity assays showed that all materials were nontoxic to HaCaT cell line and, therefore, they can be ceded for further cytotoxicity as well as genotoxicity testing and in future potentially applicable in cosmetic industry.

Keywords: PBH, liposomes, nanofibers, cyto-toxicity, cosmetics
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