Investigations of the biological effects of nanomaterials are important for assessing the risk of nanotechnology products. The present study includes the comparative investigation of the localization of core-shell gold hybrid nanostructures and native titanium dioxide nanoparticles. Changes in biochemical parameters of the treated rats in comparison to control animals were observed depending on the type of nanoparticles used. The exposure did not cause lethality, substantial behavior deviations, water and food consumption, pathomorphology of the internal organs. Besides, this study includes the investigation of biological effects of metal nanoparticles after exposure of mammalian cells. Dose- and time-dependent changes in cell viability after exposure to gold hybrid nanostructures and native titanium dioxide nanoparticles were estimated by MTT test.Keywords: Metal nanoparticles, in vitro toxicity, cell viability, MTT-test
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