SILICA DIOXIDE NANOFIBER BASED DRUG DELIVERY SYSTEM WITH SUSTAINED RELEASE

1 TOMÁNKOVÁ Hana
Co-authors:
1,2 RYSOVÁ Miroslava 3 SCHNEIDROVÁ Marie 3 SKLENÁŘOVÁ Hana
Institutions:
1 Institute for Nanomaterials, Novel Technologies and Innovation (CXi), TUL, Liberec, Czech Republic, EU, hana.tomankova@tul.cz
2 Institute of New Technologies and Applied Informatics (FM), TUL, Liberec, Czech Republic, EU
3 Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic, EU
Conference:
11th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 16th - 18th 2019
Proceedings:
Proceedings 11th International Conference on Nanomaterials - Research & Application
Pages:
336-341
ISBN:
978-80-87294-95-6
ISSN:
2694-930X
Published:
1st April 2020
Proceedings of the conference have been sent to Web of Science and Scopus for evaluation and potential indexing.
Metrics:
23 views / 6 downloads
Abstract

We developed a transdermal drug delivery system containing tetracycline as a model antibiotic for wound healing application. Our previous in vitro tests proved no cytotoxic effect nor antibacterial activity of the silica nanofiber based matrix. This study was designed to evaluate biocompatibility of our nanofiber-antibiotic system via reconstructed human skin model, and to confirm sustained release of the incorporated active compound. Further characterization showed that both moisture vapor permeability and enhanced hydrophilicity of the modified nanofibers remained consistent after functionalization. The summarized results proved that this drug delivery system is a perspective solution in potential medicated sustained release patch for wound healing.

Keywords: Silica dioxide nanofibers, sustained release, wound healing, antibiotic, topical delivery.
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