MESOPOROUS SILICA THIN FILMS FOR BIOMOLECULES SERS DETECTION

1 PERMINOVA Anastasia
Co-authors:
1 LYUTAKOV Oleksiy 1 Švorčik Vacláv
Institution:
1 VŠCHT – University of Chemistry and Technology Prague, Czech Republic, EU, perminoa@vscht.cz
Conference:
11th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 16th - 18th 2019
Proceedings:
Proceedings 11th International Conference on Nanomaterials - Research & Application
Pages:
423-427
ISBN:
978-80-87294-95-6
ISSN:
2694-930X
Published:
1st April 2020
Proceedings of the conference have been sent to Web of Science and Scopus for evaluation and potential indexing.
Metrics:
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Abstract

The functional plasmon active surfaces was designed and constructed for advanced Raman spectroscopy purposes. There is a huge demand in biochemistry and medicine for on-line observation of microorganism’s behavior, including the biofilms formation. For this goal the Raman spectroscopy measurements can be used. The obstacle we face is that the (bio)liquid may contain a lot of different sized biomolecules. To cut-off unnecessary molecules we propose the utilization of molecular sieve – mesoporous silica thin film (MSTF) deposited on plasmon active surface (periodical gold grating). Our biosensors detect trace amounts of cytotoxic ions and molecules, released from biomaterials. The plasmonic surface was functionalized with MSTF with the aim to provide the selective interaction/entrapping of the targeted objects of interest. Proposed approach also allows to directly monitor cell behavior on the variously modified surfaces and, moreover, surfaces with different morphologies. Development of proposed ideas and concepts introduces an innovative approach in the analysis of complex (bio)molecules system, get new information about the microorganism behavior as well as shed light on previously unknown phenomena in the microbiology field.

Keywords: mesoporous silica, SERS, plasmon-active surface
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