SURFACE MODIFICATION OF NANOPARTICLES FOR SUSTAINING SENSITIVITY OF SURFACE-ENHANCED RAMAN SPECTROMETRIC MEASUREMENTS IN SALINATED ENVIRONMENT

1 TYCOVA Anna
Co-authors:
1 PRIKRYL Jan 2 VANHARA Petr 1 KLEPARNIK Karel 1 FORET Frantisek
Institutions:
1 Czech Academy of Sciences, Institute of Analytical Chemistry, Brno, Czech Republic, tycova@iach.cz
2 Department of Histology and Embryology, Faculty of Science, Masaryk University, Brno, Czech Republic
Conference:
11th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 16th - 18th 2019
Proceedings:
Proceedings 11th International Conference on Nanomaterials - Research & Application
Pages:
428-433
ISBN:
978-80-87294-95-6
ISSN:
2694-930X
Published:
1st April 2020
Proceedings of the conference have been sent to Web of Science and Scopus for evaluation and potential indexing.
Metrics:
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Abstract

Surface-enhanced Raman spectrometry (SERS) represents a powerful method for analysis of a broad spectrum of analytes ranging from inorganic ions to biomolecules of high complexity. It combines the potential of Raman spectrometry for a definite identification of an analyte with remarkable sensitivity achieved by the surface enhancement effect occurring on metal nanoparticles. While low ionic strength influences positively the sensitivity of the SERS measurement, a higher level of inorganic salts leads to fast ruining of colloidal character, which completely devastates the effect of the surface enhancement. The common stabilization of nanoparticles by a layer of polymers has a negative impact on the SERS sensitivity since it shields the nanoparticle surface from the analytes. In this work, we aim at the development of the bi-ligand system of nanoparticles surface modification for improved stability of colloid in saline solution at sustaining the potential for sensitive SERS analyses. The proposed system relies on the binding of 3-mercaptopropionic acid and thiolated polyethylene glycol in a suitable ratio onto the nanoparticle surfaces. While the short chains of the acid sustain the accessibility of the surface for analytes, the polymeric structures act as a steric barrier preventing colloid aggregation.

Keywords: Bi-ligand, nanoparticle, saline solution, stability, surface-enhanced Raman spectrometry
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