CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS

1,2 BOKROVÁ Jitka
Co-authors:
1 RUČKOVÁ Michaela 1,2 MATOUŠKOVÁ Petra 1,2 PAVELKOVÁ Renata 1,2 HOOVÁ Julie 1,2 MÁROVÁ Ivana
Institutions:
1 Material Research Centre, Faculty of Chemistry, Brno University of Technology, Brno, Czech Republic, EU
2 Department of Food Chemistry and Biotechnology, Faculty of Chemistry, Brno University of Technology, Brno, Czech Republic, EU
Conference:
9th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 18th - 20th 2017
Proceedings:
Proceedings 9th International Conference on Nanomaterials - Research & Application
Pages:
739-744
ISBN:
978-80-87294-81-9
ISSN:
2694-930X
Published:
8th March 2018
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
25 views / 10 downloads
Abstract

Easy scale up of production led to an increase in cosmetic industry interest in lipid nanostructures. There are currently some liposome formulations on the market and the amount of these products will indoubtedly continue to grow. For this, detailed studies about their potential genotoxicity and cytotoxicity are neccesary.Presented work deals with preparation and characterization of liposome particles with aqueous and oil extracts of plant origin. The aim of this work was to observe cytotoxic and genotoxic effects of prepared liposomes.Total phenolics, flavonoids and antioxidant activity of plant extracts were determined using spectrophotometry as well as encapsulation efficiency. Stability of liposome particles was evaluated using zeta potential and size of liposomes was determined by dynamic light scattering. Potential genotoxic effects of liposomes were analysed using SOS Chromotest. Cytotoxicity of liposome particles was observed in human epidermal keratinocytes HEK (102-05a).Micro- and nanoparticles with encapsulated antioxidant and antimicrobial active compounds can enhance the effectiveness of cosmetics and pharmaceuticals. In this work, the potential use of liposome particles with natural plant extracts in appropriate concentration was proposed.

Keywords: liposome, cosmetics, cytotoxicity, genotoxicity, antioxidant
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