ULTRASOUND IRRADIATION TO VISUALIZE AND TRIGGER THE RELEASE OF DOXORUBICIN FROM HYBRID MICROPARTICLES

1 POSTNIKOV S. Pavel
Co-authors:
1,2 DI MARTINO Antonio 1 VLASOV S. Sergei 1 KURTUKOV V. Viktor 2 SEDLARIK Vladimir
Institutions:
1 Tomsk Polytechnic University, Lenin Av.30, 634050, Tomsk, Russian Federation
2 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr.T.Bati 5678,760 01 Zlin, Czech Republic
Conference:
9th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 18th - 20th 2017
Proceedings:
Proceedings 9th International Conference on Nanomaterials - Research & Application
Pages:
485-488
ISBN:
978-80-87294-81-9
ISSN:
2694-930X
Published:
8th March 2018
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
14 views / 6 downloads
Abstract

In the presented work the simultaneous use of ultrasound in tracking and smart release was investigated. Hybrid microparticles based on an iron core coated by a polysaccharide were prepared and loaded with doxorubicin. The possibility to trigger and control the release of the payload was demonstrated by application of ultrasound cycles at different power and time length. Results clearly indicate a direct correlation between the intensity of the release with the two parameters. A preliminary test using Sus Domestic liver demonstrates the possibility to visualize the faith of the microparticles after injection at the target site by a linear array ultrasound transducer. The dual function of the ultrasound; to visualize the position of the microparticles and afterwards trigger the release by changing the frequency was demonstrated offering a great perspective for a future biomedical application.

Keywords: Ultrasound, microparticles, stimuli-responsive release, doxorubicin, iron oxide
Scroll to Top