COMPARATIVE STUDY OF BIOLOGICAL RESPONSE OF AG AND PD NANOWIRE ARRAYS SUPPORTED ON POLYETHYLENE NAPHTHALATE FOR MEDICAL APPLICATIONS

1 POLÍVKOVÁ Markéta
Co-authors:
1 SIEGEL Jakub 1 STASZEK Marek 1 VALOVÁ Michaela 1 PIŠLOVÁ Markéta 1 ŠVORČÍK Václav
Institution:
1 Department of Solid State Engineering, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic, EU, polivkoa@vscht.cz
Conference:
9th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 18th - 20th 2017
Proceedings:
Proceedings 9th International Conference on Nanomaterials - Research & Application
Pages:
627-632
ISBN:
978-80-87294-81-9
ISSN:
2694-930X
Published:
8th March 2018
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
12 views / 5 downloads
Abstract

In recent days, advancements in nanotechnology ensure everyday applications of nanostructured noble metals, especially silver. Particularly in the medicinal applications, where they profit from their unique antibacterial effects, a serious risk of cytotoxic side-effects may occur. In this work, we studied biological (antibacterial and cytotoxic) response of commonly used silver nanostructures (nanowires, NWs), and compared them with Pd ones, as their possibly safer alternative. Both metal nanostructures were supported on biocompatible polymer - polyethylene naphthalate. The surface of metal/polymer composites was thoroughly characterized by XPS, FIB-SEM and AFM. Thereafter, biological testing of the samples was accomplished. Antibacterial properties of both, Ag and Pd NWs were examined and mutually compared by using Gram-negative bacteria Escherichia coli and Gram-positive Staphylococcus epidermidis, which commonly cause hospital-acquired infections. Finally, the comparative cytotoxic study of both types of composites was carried out using mouse embryonic fibroblasts. Such approach was chosen to determine, whether Pd nanostructures might compete with Ag ones in their medical applications.

Keywords: Silver, Palladium, Nanowires, Medical applications, Antibacterial effects, Cytotoxicity
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