Cerium oxide nanoparticles were prepared by the hydrothermal method. Simultaneous measurements of the bovine serum albumin adsorption and zeta potential determination of the (adsorption) suspensions were carried out. The samples of nanoceria with positive zeta potential adsorbed more bovine serum albumin while on the other hand, the samples with negative zeta potential exhibited little or no protein adsorption. Particle size distribution and the influence of pH and temperature on the zeta potential of the prepared CeO2 and BSA were determined. The adsorption isotherms of BSA on CeO2 were found to be of the typical Langmuir type; values of the bovine serum albumin adsorption capacities were calculated. Increasing pH led to a decrease in zeta potential and decrease in the adsorption capacity of cerium oxide nanoparticles. It was proved that the adsorption capacity of BSA on nanoceria particles increased with a rise in temperature. The maximum adsorption capacity was found for an acid (pH 4) suspension and temperature of 34 °C (am = 124 mg.g-1). Calculated thermodynamic parameters indicate that the adsorption of BSA on the ceria is an endothermic (ΔHads > 0) and spontaneous (ΔGads < 0) process. The kinetics of adsorption best fit the pseudo-second-order.Keywords: nanoceria, albumin, adsorption, zeta potential, kinetics, thermodynamics
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