NANOFIBROUS PATCHES FOR CARDIAC DRUG DELIVERY

1,2 RYSOVÁ Miroslava
Co-authors:
2 POLÁKOVÁ Dagmar 1,3 TOMÁNKOVÁ Hana 1,2 ROTKOVÁ Jana 1,2 MARTINOVÁ Lenka
Institutions:
1 Centre for Nanomaterials, Advanced Technologies and Innovation, TUL, Liberec, Czech Republic, EU, miroslava.rysova@tul.cz
2 Technical University of Liberec, Faculty of Mechatronics and Interdisciplinary Studies, Liberec, Czech Republic, EU
3 Charles University, 1st Faculty of Medicine, Institute of Physiology, Prague, Czech Republic, EU
Conference:
8th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 19th - 21st 2016
Proceedings:
Proceedings 8th International Conference on Nanomaterials - Research & Application
Pages:
478-483
ISBN:
978-80-87294-71-0
ISSN:
2694-930X
Published:
17th March 2017
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
19 views / 5 downloads
Abstract

Potential application of nanofibers in drug delivery has attracted a huge attention recently highlighting their properties including increased surface reactivity, high specific surface and improved drug bioavailability. Cardiac regenerative therapy, whereby pro-regenerative cells, drugs or growth factors are administered to myocardium has demonstrated significant potential in post-operative therapy. One of the main conditions applied on drug delivery system materials are cardiac biocompatibility, tolerability, treatment efficacy. Our objective in this study was to develop a nanofibrous patch with a short degradation time for cardiac drug delivery and evaluate its properties relevant for the application site. Silk fibroin based nanofibres were manufactured from Bombyx mori raw cocoons by degum procedure, ionic liquid dissolution and subsequent needle-less electrospinning. The electrospun nanofibres were crosslinked by alcohol dehydration. Stabilized and unstabilized nanofibrous patches were characterized in terms of morphology, chemical composition and degradation kinetics. The main objective was focused on cardiac cytotoxic effect of nanofibres and its evaluation on H9C2 rat myoblastic cell line.

Keywords: cardiac drug delivery, nanofibres, silk fibroin, biocompatibility, biodegradability
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