STUDY OF BIOCOMPATIBILITY OF MODIFIED POLYETHYLENE

1 NOVOTNA Zdenka
Co-authors:
1 LACMANOVA Veronika 2 RIMPELOVA Silvie 1 JURIK Petr 1 POLIVKOVA Marketa 3 KOLSKA Zdenka 1 SVORCIK Vaclav
Institutions:
1 Department of Solid State Engineering, University of Chemistry and Technology Prague, Prague, Czech Republic, EU, zdenka1.novotna@vscht.cz, +420 220 445 142
2 Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czech Republic, EU
3 Faculty of Science, J. E. Purkyne University, Ústí nad Labem, Czech Republic, EU
Conference:
8th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 19th - 21st 2016
Proceedings:
Proceedings 8th International Conference on Nanomaterials - Research & Application
Pages:
572-577
ISBN:
978-80-87294-71-0
ISSN:
2694-930X
Published:
17th March 2017
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
36 views / 11 downloads
Abstract

Polyethylene (PE) is a synthetic polymer used for biomedical applications and tissue engineering. Surface modification of this material relates to changes of its surface hydrophilicity, chemistry, morphology, microstructure, roughness, and topography, all influencing its biological response. This our research was focused on modification of PE by argon plasma discharge and then grafting with biologically active polyethylene glycol (PEG) with the aim to enhance its cytocompatibility of the cell lines L929 of mouse fibroblast. The surface properties of pristine PE and its grafted counterparts were studied by different experimental techniques: X-ray spectroscopy, goniometry, Atomic Force Microscopy and electrokinetic analysis (zeta potential). Our results show that grafting of PEG leads to higher wettability, surface roughness, and thus the adhesion and proliferation of cultured cells.

Keywords: Polyethylene, plasma treatment, polyethylene glycols grafting, surface properties, cell growth
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