INTERACTION OF DRUGS WITH SOIL ORGANIC MATTER STUDIED BY MICROCALORIMETRY

1 KROUSKÁ Jitka
Co-authors:
1 PAPKO Nadezhda 1 KLUČÁKOVÁ Martina
Institution:
1 Brno University of Technology, Faculty of Chemistry, Brno, Czech Republic, EU, krouska@fch.vut.cz
Conference:
14th International Conference on Nanomaterials - Research & Application, OREA Congress Hotel Brno, Czech Republic, EU, October 19 - 21, 2022
Proceedings:
Proceedings 14th International Conference on Nanomaterials - Research & Application
Pages:
255-259
ISBN:
978-80-88365-09-9
ISSN:
2694-930X
Published:
23rd November 2022
Proceedings of the conference have already been published in Scopus and we are waiting for evaluation and potential indexing in Web of Science.
Metrics:
201 views / 101 downloads
Abstract

The usage of pharmaceuticals increases worldwide every year. The residues of these substances are excreted by the human or animal bodies and thus come into direct contact with the environment, mainly soils and ground water. The accumulation of pharmaceuticals in natural ecosystems may be problematic in the future therefore the knowledge of their behaviour, transport and interactions in the ecosystems is essential for their treatment. The most reactive substances in soils are humic as well as fulvic substances. Two fulvic acids stand as the model reactants with different pharmaceuticals in this study. These reactive compounds contain several kinds of active functional groups, such as hydrophilic hydroxylic or carboxylic groups, and also diverse hydrophobic structures. The interactions between fulvic acids and solutions of pure drugs were studied by isothermal titration calorimetry. The aim of the study was to observe the heat effects of the interactions and to describe the intensity of the binding process.

Keywords: Humic substances, drug, interaction, microcalorimetry

© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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