DEGRADATION OF POLYCAPROLACTONE ELECTROSPUN MATERIALS - METHODS OF ANALYSIS

1 HAVLÍČKOVÁ Kristýna
Co-authors:
2 ŘEZANKA Michal 3 KOBERA Libor 1 KUŽELOVÁ KOŠŤÁKOVÁ Eva 1 LUKÁŠ David 1 JENČOVÁ Věra
Institutions:
1 Technical University of Liberec, Faculty of Science, Humanities and Education, Departmnt of Chemistry, Liberec, Czech Republic, EU, kristyna.havlickova@tul.cz
2 Technical University of Liberec, Institute for Nanomaterials, Advanced Technology and Innovation, Department of Nanochemistry, Liberec, Czech Republic, EU, michal.rezanka@tul.cz
3 Institute of Macromolecular Chemistry CAS, Czech Academy of Sciences, Prague, Czech Republic, EU, kobera@imc.cas.cz
Conference:
13th International Conference on Nanomaterials - Research & Application, Orea Congress Hotel Brno, Czech Republic, EU, October 20 - 22, 2021
Proceedings:
Proceedings 13th International Conference on Nanomaterials - Research & Application
Pages:
246-251
ISBN:
978-80-88365-00-6
ISSN:
2694-930X
Published:
22nd November 2021
Proceedings of the conference have already been published in Scopus and we are waiting for evaluation and potential indexing in Web of Science.
Metrics:
156 views / 111 downloads
Abstract

Biodegradable electrospun materials are widely used for medical application. Polycaprolatone is polymer suitable for electrospinning technology and is very often used to create nanofibrous scaffolds for tissue engineering. The time to disintegration or biodegradation of such materials is very important here. However, testing is not entirely easy. It is not possible to create exactly body-like conditions in vitro. Moreover, it is not easy to find suitable analytical methods that would show exactly what happens in the nanofibrous polycaprolactone electrospun samples at certain stages of degradation, ie how the internal structure of decaying nanofibers changes. This paper describes the traditional use of methods for testing polycaprolatone nanofibers by enzymatically catalysed degradation. Morphological changes are studied using scanning electron microscope images. However, it also offers a non-traditional analysis of polycaprolactone electrospun materials using the ssNMR method.

Keywords: Electrospinning, nanofibers, enzymatic degradation, solid state NMR

© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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