In this work, silica dioxide nanofibers (SiNFs) were prepared by sol-gel method followed by electrospinning to be further functionalized by silanization. To improve the chemical modification, plasma treatment of various parameters was applied and the effect on the surface properties before and after plasma activation was studied. The increase of the amine groups accessible on the surface after the combined physico-chemical modification, together with the improved hydrophilicity of the so-modified inorganic nanomats, were demonstrated. Finally, the optimal parameters of the SiNFs plasma activation have been applied and their biocompatibility, as well as the time stability of the physical modification, have been proven.Keywords: Silica dioxide nanofibers, silanization, plasma treatment
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