MICROSCOPIC STUDY OF MULTIFUNCTIONAL DRUG MOLECULE ADHESION TO ELECTRONIC BIOSENSORS COATED WITH DIAMOND AND GOLD NANOPARTICLES

1 FINSTERLE Tomáš
Co-authors:
1 PILARČÍKOVÁ Ivana 1 ALI BLÁHOVÁ Ilona 2 POTOCKÝ Štěpán 2 KROMKA Alexander 2 UKRAINTSEV Egor 3 NEPOVIMOVÁ Eugenie 3 MUSÍLEK Kamil 3 KUČA Kamil 1 REZEK Bohuslav
Institutions:
1 Faculty of Electrical Engineering, Czech Technical University in Prague, Czech Republic, finsttom@fel.cvut.cz
2 Institute of Physics, Czech Academy of Sciences, Prague, Czech Republic
3 Faculty of Science, University of Hradec Kralove, Czech Republic
Conference:
10th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 17th - 19th 2018
Proceedings:
Proceedings 10th International Conference on Nanomaterials - Research & Application
Pages:
380-385
ISBN:
978-80-87294-89-5
ISSN:
2694-930X
Published:
28th February 2019
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
28 views / 12 downloads
Abstract

The easy and fast detection of drug content and concentration levels is demanded in biological research as well as in clinical practice. Here we study on microscopic level how nanodiamonds and gold nanoparticles interact with a multifunctional drug molecule directly on a biosensor surface. The sensors are made of interdigitated Au electrodes coated by 5 nm hydrogenated or oxidized nanodiamonds and further combined with Au colloidal nanoparticles (size 20 nm) providing nanoscale composite (spacing 100 nm). Atomic force microscopy is employed to measure local tip-surface adhesion forces and surface topography. AFM adhesion maps show that the drug binds to all types of nanoparticles and the adhesion is also significantly influenced by the substrates on which the nanoparticles are deposited. Role of local AFM tip interaction with nanostructured surface is also discussed.

Keywords: Biosensors, nanoparticles, nanodiamonds, Alzheimer drugs
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