IN VIVO ANTIBACTERIAL STUDY OF ZINC PHOSPHATE-BASED NANOPARTICLES

1 KOCIOVA Silvia
Co-authors:
1 VALECKOVA Vendula 1 BYTESNIKOVA Zuzana 2 HORKY Pavel 1,3 KOPEL Pavel 1,3 ADAM Vojtech 1,3 SMERKOVA Kristyna
Institutions:
1 Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic, xkociova@mendelu.cz
2 Department of Animal Nutrition and Forage Production, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic
3 Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic
Conference:
10th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 17th - 19th 2018
Proceedings:
Proceedings 10th International Conference on Nanomaterials - Research & Application
Pages:
511-516
ISBN:
978-80-87294-89-5
ISSN:
2694-930X
Published:
28th February 2019
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
36 views / 8 downloads
Abstract

In animal nutrition, the nanotechnology is mostly used for the preparation of nanominerals, especially trace minerals, due to their low bioavailability. These nanominerals also showed advantageous effects at lower doses compared to conventional minerals. In addition, nanominerals can improve digestive efficacy, immunity and overall performance in livestock. In that case, we suggested and synthesized four types of zinc phosphate-based nanoparticles (ZnNPs), which achieved a significant antibacterial activity. After successful in vitro testing, we realized also in vivo study. We investigated the effect of zinc nanoparticles on rats after oral administration. Among others, the influence on total aerobic bacteria and coliforms in rat feces at day 10 or day 30 of treatment was monitored. In general, it has been observed a decrease of total aerobic and coliform bacteria population compared to untreated control group.

Keywords: Antibiotics, antimicrobial activity, zinc nanoparticles, nanominerals, rats
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