DEVELOPMENT OF FIBROUS IMPLANT FOR THE TREATMENT OF GLAUCOMA

1 KLAPSTOVA Andrea
Co-authors:
1 VRSINSKA Klara 1 HORAKOVA Jana 1 SAMAN Ales 2 SHYNKARENKO Andrii 1 LUKAS David
Institutions:
1 Technical University of Liberec, Faculty Of Textile Engineering, Department of Nonwovens and Nanofibrous Materials, Liberec, Czech Republic, EU, andrea.klapstova@tul.cz
2 Technical University of Liberec, Faculty of Mechanical Engineering, Department of Manufacturing Systems and Automation, Liberec, Czech Republic, EU
Conference:
8th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 19th - 21st 2016
Proceedings:
Proceedings 8th International Conference on Nanomaterials - Research & Application
Pages:
497-502
ISBN:
978-80-87294-71-0
ISSN:
2694-930X
Published:
17th March 2017
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
17 views / 5 downloads
Abstract

This article deals with the development of fibrous non-biodegradable drainage device for the treatment of glaucoma disease. Currently produced implants are often associated with hypotony, undesired fibrosis, tissue damages around the implant and many others [1]. Nanofiber implant has great potential to alleviate or completely eliminate these problems. The main goal of this work was a creation of the drain for safety drainage of intraocular fluid from the patient eye to achieve a normal intraocular pressure. The small-diameter tubular implant (<1 mm) was developed by the use of the electrospinning technology. The structure was composed of two parts, by using special types of collectors. The outer part was formed of non-biodegradable material that is resistant to cell growth. The inner supporting part was formed of hydrophilic material which is also resistant to cell growth. This part prevents the compression of the outer material and a total blockage of the drain. The special structure supports the drainage of fluid. Material was subjected to morphological structures, liquid transport tests and in-vitro cell adhesion tests. First results show great potential in the use of the implant in treatment of glaucoma disease.

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