DEVELOPMENT OF THERANOSTIC AGENTS BASED ON IRON OXIDE-GADOLINIUM-CHITOSAN FOR CONTROLLED RELEASE OF DOXORUBICIN

1 DI MARTINO Antonio
Co-authors:
2,3 GUSELNIKOVA A. Olga 2 KURTUKOV V. Viktor 2 POSTNIKOV S. Pavel 1 SEDLARIK Vladimir
Institutions:
1 Tomas Bata University in Zlin, University Institute, Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic, EU
2 National Research Tomsk Polytechnic University, Lenin Av. 30, 634050, Tomsk, Russian Federation
3 University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic, EU
Conference:
8th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 19th - 21st 2016
Proceedings:
Proceedings 8th International Conference on Nanomaterials - Research & Application
Pages:
525-529
ISBN:
978-80-87294-71-0
ISSN:
2694-930X
Published:
17th March 2017
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
18 views / 9 downloads
Abstract

Herein we report a theranostic system based on iron oxide-gadolinium nanoparticles coated by chitosan as a dual contrast agent for magnetic resonance imaging and controlled delivery application. Iron oxide nanoparticles were prepared by reduction of iron (III) chloride followed by surface modification using arenediazonium tosylate and diethylenetriaminepentaacetic acid for Gd(III) complexation. Nanoparticles were loaded with the anticancer drug doxorubicin and coated by low molecular weight chitosan to improve stability in solution and control the release of the drug. Dynamic light scattering, ζ-potential, thermogravimetric analysis, attenuated total refraction infrared spectroscopy and magnetic hysteresis curves reveal the success of surface modification and coating process. The amount of Gd(Gd(III) complexed and doxorubicin loaded were assessed by UV-Vis. Release studies were carried out in simulated physiological conditions. Results indicate that the obtained iron oxide-Gd(III)nanoparticles) nanoparticles coated by chitosan are stable up to one month in physiological conditions and magnetic response is slightly decreased. The MRI analysis, doxorubicin high encapsulation efficiency and sustained release trend suggests that the presented system represents an interesting platform for the development of future theranostic agents.

Keywords: Iron oxide nanoparticles, gadolinium, chitosan, theranostic, controlled release, doxorubicin
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