Pure silica nanofibers prepared by electrospinning from the sol-gel were reported to be successfully used in tissue engineering due to their biocompatibility, non-toxicity and biodegradability. This study deals with the possible mechanical degradation of silica nanofibers in vitro that have been pulverized down to the size of nanoparticles. The resulting fragments prepared in distilled water were compared to those that were removed up after two weeks of dissolution in saline adjusted to pH 7.4 and at 37 °C (values simulating the environment of some body fluids). The nanoparticles were measured using the Zetasizer device and compared to the data obtained by scanning electron microscope (SEM) and optical microscope.Keywords: Silica nanofibers, silica nanoparticles, degradation, aggregation
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