This study deals with modifications of inorganic-organic nanofibers to optimize the manufacturing process and to ensure long-term antibacterial activity of the nanofibers. The nanofibers material is combination of poly(vinyl alcohol) and silica. There are presented two methods of nanofibers´ structure modifications: i) surface functionalization of the nanofibers by silver and copper nanoparticles, and ii) modification of initial sol by antiseptic additive. The both modifications methods ensure significant antibacterial activity of inorganic-organic nanofibers, which was proven by in-vitro antibacterial tests. This novel material shows a big potential for wound dressing applications.Keywords: Silica nanofibers, antibacterial activity, wound dressing, silver ions, copper ions
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