BIOCOMPATIBILITY OF METALS AND THEIR SURFACES

1 Homolková Monika
Co-authors:
1 Březina Vítězslav
Institution:
1 University of South Bohemia in České Budějovice, FFPW, CENAKVA, Institute of Complex Systems, Nove Hrady, Czech Republic, EU, homolkova@frov.jcu.cz, Vitezslav.brezina@gmail.com
Conference:
24th International Conference on Metallurgy and Materials, Hotel Voronez I, Brno, Czech Republic, EU, June 3rd - 5th 2015
Proceedings:
Proceedings 24th International Conference on Metallurgy and Materials
Pages:
964-969
ISBN:
978-80-87294-58-1
ISSN:
2694-9296
Published:
12th January 2015
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
134 views / 29 downloads
Abstract

Metals and their alloys are often used in the production of implants or stents, and are applied to a living organism. For this application it is necessary to provide for biocompatibility, i.e. determine the likely response of the organism to the embedded metal material. Reactions of cell populations in vitro or ex vivo are primary biocompatibility tests. Determination of cytotoxicity is inefficient for these purposes; it is necessary to find out the degree of tolerance of the cell population to the implanted metallic material before the subsequent tests are conducted on experimental animals. Special test trials in patients with allergy to some of the components of the selected alloy are the peak of the pyramid. In the statement we deal with reaction of animal cell lines to certain metals and alloys used in medicine that are examined in the system of time lapse cinephotomicrography of live cell populations in vitro. Cell lines are scanned in the direct contact with a metal, possibly metal alloy for 72 hours, and subsequently the direct reaction of biocompatibility is evaluated.

Keywords: Metals, metal alloys, cell line, biocompatibility

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